tert-butyl N-(2-oxoethyl)carbamate → Tert-butyl (2-(4-(3-acrylamido-4-((6-(3-(2,6-dichloro-3,5-dimethoxyphenyl)-1-methylureido)pyrimidin-4-yl)amino)phenyl)piperazin-1-yl)ethyl)carbamate

反応式

FC(F)(F)C(O)=O.[Cl:8][C:9]1[C:14]([O:15][CH3:16])=[CH:13][C:12]([O:17][CH3:18])=[C:11]([Cl:19])[C:10]=1[NH:20][C:21](=[O:48])[N:22]([C:24]1[N:29]=[CH:28][N:27]=[C:26]([NH:30][C:31]2[CH:36]=[CH:35][C:34]([N:37]3[CH2:42][CH2:41][NH:40][CH2:39][CH2:38]3)=[CH:33][C:32]=2[NH:43][C:44](=[O:47])[CH:45]=[CH2:46])[CH:25]=1)[CH3:23].[C:49]([O:53][C:54](=[O:59])[NH:55][CH2:56][CH:57]=O)([CH3:52])([CH3:51])[CH3:50].C([BH3-])#N.[Na+]>C1COCC1.CO>[C:44]([NH:43][C:32]1[CH:33]=[C:34]([N:37]2[CH2:38][CH2:39][N:40]([CH2:57][CH2:56][NH:55][C:54](=[O:59])[O:53][C:49]([CH3:52])([CH3:51])[CH3:50])[CH2:41][CH2:42]2)[CH:35]=[CH:36][C:31]=1[NH:30][C:26]1[CH:25]=[C:24]([N:22]([CH3:23])[C:21]([NH:20][C:10]2[C:9]([Cl:8])=[C:14]([O:15][CH3:16])[CH:13]=[C:12]([O:17][CH3:18])[C:11]=2[Cl:19])=[O:48])[N:29]=[CH:28][N:27]=1)(=[O:47])[CH:45]=[CH2:46]