Thiazolidinedione → HCID 22342547、化合物

反応式

[S:1]1CC(=O)[NH:3][C:2]1=[O:7].[H-].[Na+].[Li+].[CH3:11]C([N-]C(C)C)C.CI.C1[CH2:24][O:23][CH2:22][CH2:21]1>>[CH3:11][O:7][C:2]1[S:1][CH:21]=[C:22]([O:23][CH3:24])[N:3]=1

参加物

反応物 5

HCID 5437Thiazolidinedione

HCID 6328Methyl iodide

HCID 8028Tetrahydrofuran

HCID 24758Sodium hydride

HCID 2724682Lithium diisopropylamide

生成物 1

HCID 22342547HCID 22342547、化合物

実験手順

To a stirred solution of 2,4-thiazolidindione (0.01 mol) in a solvent such as THF is added from 2 to 4 mol equivalents of a non-nucleophilic base such as sodium hydride or LDA, followed by methyl iodide, and the mixture is stirred. Reaction progress may be followed by TLC or HPLC. When a sufficient amount of the desired product is formed, the mixture is partitioned between ethyl acetate and water. The organic layer is washed with brine, dried over sodium sulfate, and rotary evaporated to give 2,4-dimethoxythiazole, which may be purified, if needed or desired, by chromatography on silica gel or crystallization.

後処理

customReaction progress

出典と根拠

ORDレコード: ord-9dc56365222c4a989f4260db0127b25d
出典データセット: uspto-grants-2005_08
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US06924276B2

反応ノート

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