Benzaldehyde → 2-(Benzylamino)-2-methylpropane-1,3-diol

HRID 584227

反応式

HRID 584227 の反応式
[CH:1](=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH2:9][C:10]([CH3:15])([CH2:13][OH:14])[CH2:11][OH:12].[BH4-].[Na+].[OH-].[Na+]>CO.C(OCC)(=O)C>[CH2:1]([NH:9][C:10]([CH3:15])([CH2:13][OH:14])[CH2:11][OH:12])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

7

反応物 4

HCID 240BenzaldehydeHCID 15312-Amino-2-methyl-1,3-propanediolHCID 14798Sodium HydroxideHCID 4311764Sodium borohydride

生成物 1

HCID 1987392-(Benzylamino)-2-methylpropane-1,3-diol

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 8857Ethyl Acetate溶媒

実験手順

Benzaldehyde (17.4 ml) was added dropwise to a solution of 2-amino-2-methyl-1,3-propanediol (20 g) in methanol (200 ml) at 0° C. and the whole was stirred at room temperature for 2 hours. Sodium borohydride (11.5 g) was added thereto in portions at 0° C. and the mixture was stirred for 10 minutes. 1N Sodium hydroxide solution and ethyl acetate were added and the organic layer was separated, dried over magnesium sulfate, and evaporated in vacuo to give 2-benzylamino-2-methyl-1,3-propanediol (28.54 g).

後処理

  1. stirringin portions at 0° C. and the mixture was stirred for 10 minutes
  2. customthe organic layer was separated
  3. dry with materialdried over magnesium sulfate
  4. customevaporated in vacuo

出典と根拠

ORDレコード
ord-d6eaeaec6c984751a5cd14c9cb938246
出典データセット
uspto-grants-2005_08
特許番号
US06924278B2

関連ノート

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