Methanol → 4-[2-(2-Furyl)-5-methyl-4-oxazolylmethoxy]-3-methoxybenzyl alcohol

HRID 584401

反応式

HRID 584401 の反応式
[BH4-].[Na+].[O:3]1[CH:7]=[CH:6][CH:5]=[C:4]1[C:8]1[O:9][C:10]([CH3:25])=[C:11]([CH2:13][O:14][C:15]2[CH:22]=[CH:21][C:18]([CH:19]=[O:20])=[CH:17][C:16]=2[O:23][CH3:24])[N:12]=1.CO.O>O1CCCC1>[O:3]1[CH:7]=[CH:6][CH:5]=[C:4]1[C:8]1[O:9][C:10]([CH3:25])=[C:11]([CH2:13][O:14][C:15]2[CH:22]=[CH:21][C:18]([CH2:19][OH:20])=[CH:17][C:16]=2[O:23][CH3:24])[N:12]=1

参加物

6

反応物 4

HCID 887MethanolHCID 962WaterHCID 4311764Sodium borohydrideHCID 223446304-[2-(2-Furyl)-5-methyl-4-oxazolylmethoxy]-3-methoxybenzaldehyde

生成物 1

HCID 537700494-[2-(2-Furyl)-5-methyl-4-oxazolylmethoxy]-3-methoxybenzyl alcohol収率 101.4%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

Sodium borohydride (825 mg) was added to a solution of 4-[2-(2-furyl)-5-methyl-4-oxazolylmethoxy]-3-methoxybenzaldehyde (6.84 g) in tetrahydrofuran (50 ml)-methanol (50 ml) at 0° C. After stirring for 1 hour, the reaction mixture was poured into water to give 4-[2-(2-furyl)-5-methyl-4-oxazolylmethoxy]-3-methoxybenzyl alcohol (6.98 g, yield 92%) as crystals.

出典と根拠

ORDレコード
ord-da1b6e65df5a40d6942dd5ec9d7c5de4
出典データセット
uspto-grants-2005_08
特許番号
US06924300B2

関連ノート

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