Ammonia → 4-Iodobenzoyl isocyanate

HRID 59357

反応式

HRID 59357 の反応式
[I:1][C:2]1[CH:10]=[CH:9][C:5]([C:6](O)=[O:7])=[CH:4][CH:3]=1.[C:11](Cl)(=[O:15])C(Cl)=O.[NH3:17].C(Cl)Cl>C1COCC1>[I:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([N:17]=[C:11]=[O:15])=[O:7])=[CH:4][CH:3]=1

参加物

6

反応物 4

HCID 222AmmoniaHCID 6344DichloromethaneHCID 120854-Iodobenzoic acidHCID 65578Oxalyl chloride

生成物 1

HCID 149137404-Iodobenzoyl isocyanate

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

The title compound was prepared according to the procedures described in step-2 and step-3 of Intermediate-26 by using 4-iodo benzoic acid (2.0 g), oxalyl chloride (1.0 ml), ammonia gas, DCM (20 mL), THF (20 mL) to afford 1.5 g of the desired product. 1H NMR (400 MHz, DMSO d6): δ 7.17 (br s, 1H), 7.64 (d, 2H), 8.01 (s, 2H); MS (m/z): 461.14 (M+H)+.

後処理

  1. customThe title compound was prepared

出典と根拠

ORDレコード
ord-c2114230e7974a47b00e7b91356fcf1c
出典データセット
uspto-grants-2016_09
特許番号
US09439890B2

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