Ammonium formate → 4-hydroxy-1-(3-methylbutyl)-1H-pyridin-2-one

HRID 601419ノート

反応式

HRID 601419 の反応式
C([O:8][C:9]1[CH:14]=[CH:13][N:12]([CH2:15][CH2:16][CH:17]([CH3:19])[CH3:18])[C:11](=[O:20])[CH:10]=1)C1C=CC=CC=1.C([O-])=O.[NH4+]>O1CCCC1.[OH-].[OH-].[Pd+2]>[OH:8][C:9]1[CH:14]=[CH:13][N:12]([CH2:15][CH2:16][CH:17]([CH3:18])[CH3:19])[C:11](=[O:20])[CH:10]=1

参加物

5

反応物 2

HCID 2723923Ammonium formateHCID 670639744-(benzyloxy)-1-isopentyl-2(1H)-pyridinone

生成物 1

HCID 668856654-hydroxy-1-(3-methylbutyl)-1H-pyridin-2-one収率 100%

試薬・触媒・溶媒 2

HCID 9942167Palladium hydroxide触媒HCID 8028Tetrahydrofuran溶媒

実験手順

The product of Example 457A (0.452 g, 1.67 mmol) in tetrahydrofuran (20 mL) was treated with ammonium formate (0.30 g, 5.01 mmol) and a catalytic amount of 20% palladium hydroxide on carbon at 60° C. for 2 hours. The reaction was filtered through diatomaceous earth and the filtrate concentrated under reduced pressure to provide the title compound (0.30 g, 100%).

後処理

  1. filtrationThe reaction was filtered through diatomaceous earth
  2. concentrationthe filtrate concentrated under reduced pressure

出典と根拠

ORDレコード
ord-9205140998274540b5ea96a703301671
出典データセット
uspto-grants-2011_03
特許番号
US07902203B2

反応ノート

読み込み中…