4-Bromobiphenyl → 4-BROMO-4'-SULFOBIPHENYL

HRID 604697ノート

反応式

HRID 604697 の反応式
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)=[CH:4][CH:3]=1.Cl[S:15]([OH:18])(=[O:17])=[O:16]>C(Cl)(Cl)Cl>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[CH:13]=[CH:12][C:11]([S:15]([OH:18])(=[O:17])=[O:16])=[CH:10][CH:9]=2)=[CH:6][CH:7]=1

参加物

4

反応物 2

HCID 71014-BromobiphenylHCID 24638Chlorosulfonic acid

生成物 1

HCID 45247074-BROMO-4'-SULFOBIPHENYL収率 92%

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒

実験手順

A 500 mL round-bottom-flask equipped with an addition funnel, stirring bar, and gas inlet was charged with 4-bromo-biphenyl (50 g, 0.215 mol) and chloroform (200 mL) then purged with nitrogen. Chlorosulfonic acid (18 mL, 0.27 mol) was added dropwise to the solution from the addition funnel then stirred for 1 hour. The resulting precipitate was collected by vacuum filtration, washed with cold chloroform, and dried under vacuum to give 61.97 g of 4′-bromo-biphenyl-4-sulfonic acid (92% yield).

後処理

  1. customA 500 mL round-bottom-flask equipped with an addition funnel
  2. customthen purged with nitrogen
  3. stirringthen stirred for 1 hour
  4. filtrationThe resulting precipitate was collected by vacuum filtration
  5. washwashed with cold chloroform
  6. customdried under vacuum

出典と根拠

ORDレコード
ord-8e8a19e18e314e7689fa1daf4f9bae08
出典データセット
uspto-grants-2011_03
特許番号
US07910653B2

反応ノート

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