4-Chloroanisole → 4-Methoxy-4'-trifluoromethyl-biphenyl

HRID 607635ノート

反応式

HRID 607635 の反応式
COc1ccc(Cl)cc1.OB(O)c1ccc(C(F)(F)F)cc1>C1=C\CC/C=C\CC/1.C1=C\CC/C=C\CC/1.C1COCCO1.O.O=P([O-])([O-])[O-].[K+].[K+].[K+].[Ni].c1ccc(CP(Cc2ccccc2)Cc2ccccc2)cc1>COc1ccc(-c2ccc(C(F)(F)F)cc2)cc1

参加物

8

反応物 2

HCID 121674-ChloroanisoleHCID 27343894-(Trifluoromethyl)phenylboronic acid

生成物 1

HCID 112074784-Methoxy-4'-trifluoromethyl-biphenyl収率 67%

試薬・触媒・溶媒 5

HCID 962Water試薬HCID 62657Potassium Phosphate, Tribasic試薬HCID 82101Phosphine, tris(phenylmethyl)-触媒HCID 6433264Bis(1,5-cyclooctadiene)nickel触媒HCID 312751,4-Dioxane溶媒4 回

反応条件

温度
60 °C

実験手順

pre-ligate Ni(cod)2 and phosphine ligand in dioxane for 15 minutes in a separate plate

後処理

  1. additionDilute with acetonitrile
  2. aliquot手順は記録されていません
  3. customDiluent solution was made in 1 L batches with 950 mL acetonitrile, 25 mL water, 25 mL glacial acetic acid, and 53 mg 4,4’-di-tert-butylbiphenyl as an external standard (0.2 equiv standard per reaction). Aliquot taken from each well (47 ul) is added into 753 ul of diluent solution

出典と根拠

ORDレコード
ord-2294f6c459334e2db0c3981c1479f313
出典データセット
Ni-catalyzed Suzuki Miyaura cross-coupling
元リンク
出典を表示

反応ノート

読み込み中…