Methyl chloroformate → Benzoic acid, 4-(1-methylethenyl)-, methyl ester

HRID 610105

反応式

HRID 610105 の反応式
Cl[C:2]1[CH:10]=[CH:9][C:5]([C:6]([CH3:8])=[CH2:7])=[CH:4][CH:3]=1.[Mg].Cl[C:13]([O:15][CH3:16])=[O:14]>C1COCC1>[C:6]([C:5]1[CH:9]=[CH:10][C:2]([C:13]([O:15][CH3:16])=[O:14])=[CH:3][CH:4]=1)([CH3:8])=[CH2:7]

参加物

5

反応物 3

HCID 6586Methyl chloroformateHCID 743814-Chloro-alpha-methylstyreneHCID 5462224Magnesium

生成物 1

HCID 11275336Benzoic acid, 4-(1-methylethenyl)-, methyl ester

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

Preparation of the Grignard compound of 4-chloro-α-methylstyrene by means of Rieke magnesium in THF under reflux and subsequent reaction with 0.95 equivalents of methyl chloroformate at RT. Aqueous working up, extraction with ethyl acetate and column chromatography using cyclohexane/ethyl acetate 85:15 affords methyl 4-isopropenylbenzoate as colorless crystals.

後処理

  1. temperatureunder reflux
  2. extractionextraction with ethyl acetate and column chromatography

出典と根拠

ORDレコード
ord-0c66f3c754bd40ea943d24950051c2a9
出典データセット
uspto-grants-1999_12
特許番号
US05998481

関連ノート

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