Triethylamine → 3-Isoquinolinecarboxamide, 1-(2-chlorophenyl)-N,N-dipropyl-

HRID 615391

反応式

HRID 615391 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[CH:11]=[C:10]([C:18]([OH:20])=O)[N:9]=1.C(N(CC)CC)C.ClC(OCC)=O.[CH2:34]([NH:37][CH2:38][CH2:39][CH3:40])[CH2:35][CH3:36]>C(Cl)(Cl)Cl>[CH2:34]([N:37]([CH2:38][CH2:39][CH3:40])[C:18]([C:10]1[N:9]=[C:8]([C:3]2[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=2[Cl:1])[C:17]2[C:12]([CH:11]=1)=[CH:13][CH:14]=[CH:15][CH:16]=2)=[O:20])[CH2:35][CH3:36]

参加物

6

反応物 4

HCID 8471TriethylamineHCID 8902DipropylamineHCID 10928Ethyl chloroformateHCID 110005543-Isoquinolinecarboxylicacid, 1-(2-chlorophenyl)-

生成物 1

HCID 110576563-Isoquinolinecarboxamide, 1-(2-chlorophenyl)-N,N-dipropyl-収率 76.2%

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒

実験手順

Operations are carried out as for Example 7, starting from 1.42 g of 1-(2-chlorophenyl) isoquinoline 3-carboxylic acid, 0.58 g of triethylamine, 0.62 g of ethyl chloroformate and 0.66 g of N-propyl propylamine in 50 ml of chloroform. 1.40 g of N,N-dipropyl 1-(2-chloro phenyl) isoquinoline 3-carboxamide, melting at 101° C., are obtained.

出典と根拠

ORDレコード
ord-7dd1cd01cc0444419ddd184d7320cb67
出典データセット
uspto-grants-1985_02
特許番号
US04499094

関連ノート

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