Pyridine → 2-bromo-2,3-dihydro-1H-indene

HRID 615693

反応式

HRID 615693 の反応式
[CH2:1]1[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3][CH:2]1O.N1C=CC=CC=1.P(Br)(Br)[Br:18]>C(Cl)(Cl)Cl>[Br:18][CH:2]1[CH2:3][C:4]2[C:9](=[CH:8][CH:7]=[CH:6][CH:5]=2)[CH2:1]1

参加物

5

反応物 3

HCID 1049PyridineHCID 24614Phosphorus tribromideHCID 779362-Indanol

生成物 1

HCID 109654632-bromo-2,3-dihydro-1H-indene

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒

反応条件

温度
0 °C

実験手順

To 80 gms of 2-indanol in 200 ml of chloroform was added 12 ml of pyridine. The solution was cooled to 0° C. with an ice bath, and 64 ml of phosphorous tribromide slowly added over 30 minutes. The ice bath was removed, and the solution was refluxed for 1 hour, and let stand overnight.

後処理

  1. customThe ice bath was removed
  2. temperaturethe solution was refluxed for 1 hour

出典と根拠

ORDレコード
ord-b54c7438a02d4835acdf095dca28bab3
出典データセット
uspto-grants-1985_02
特許番号
US04500713

関連ノート

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