1-Iodopropane → Piperidine, 3-(3,4-dimethoxyphenyl)-1-propyl-

HRID 616031ノート

反応式

HRID 616031 の反応式
[CH2:1](I)[CH2:2][CH3:3].[CH3:5][O:6][C:7]1[CH:8]=[C:9]([CH:15]2[CH2:20][CH2:19][CH2:18][NH:17][CH2:16]2)[CH:10]=[CH:11][C:12]=1[O:13][CH3:14]>C(Cl)(Cl)Cl.[Ag]=O>[CH2:1]([N:17]1[CH2:18][CH2:19][CH2:20][CH:15]([C:9]2[CH:10]=[CH:11][C:12]([O:13][CH3:14])=[C:7]([O:6][CH3:5])[CH:8]=2)[CH2:16]1)[CH2:2][CH3:3]

参加物

5

反応物 2

HCID 336431-Iodopropane2 回HCID 129379213-(3,4-Dimethoxyphenyl)piperidine

生成物 1

HCID 11300035Piperidine, 3-(3,4-dimethoxyphenyl)-1-propyl-

試薬・触媒・溶媒 2

HCID 92152Silver(II) oxide触媒2 回HCID 6212Chloroform溶媒

反応条件

温度
20 °C

実験手順

2 g of silver oxide and then 2 ml of propyl iodide were added to a solution of 4 g of 3-(3',4'-dimethoxyphenyl)-piperidine in 20 ml of chloroform and the mixture was stirred for 8 hours at 20° C under an inert atmosphere. Another 1 g of silver oxide and 1 ml of propyl iodide were added and the mixture was stirred for 15 hours. The mixture was filtered and the filtrate was evaporated to dryness. The residue was chromatographed over silica gel and eluted with a 6-3-1 cyclohexane-chloroform-triethylamine mixture to obtain 3.2 g of N-propyl-3-(3',4'-dimethoxyphenyl)-piperidine.

後処理

  1. stirringthe mixture was stirred for 15 hours
  2. filtrationThe mixture was filtered
  3. customthe filtrate was evaporated to dryness
  4. customThe residue was chromatographed over silica gel
  5. washeluted with a 6-3-1 cyclohexane-chloroform-triethylamine mixture

出典と根拠

ORDレコード
ord-ace686240db543af8e6e1562059e4202
出典データセット
uspto-grants-1978_02
特許番号
US04072685

反応ノート

読み込み中…