5,8,11,14,17-Eicosapentaenoic Acid → 5,8,11,14,17-Eicosapentaenoyl chloride

HRID 631760

反応式

HRID 631760 の反応式
[C:1]([OH:22])(=O)[CH2:2][CH2:3][CH2:4][CH:5]=[CH:6][CH2:7][CH:8]=[CH:9][CH2:10][CH:11]=[CH:12][CH2:13][CH:14]=[CH:15][CH2:16][CH:17]=[CH:18][CH2:19][CH3:20].C(Cl)(=O)C([Cl:26])=O>C(Cl)(Cl)Cl>[C:1]([Cl:26])(=[O:22])[CH2:2][CH2:3][CH2:4][CH:5]=[CH:6][CH2:7][CH:8]=[CH:9][CH2:10][CH:11]=[CH:12][CH2:13][CH:14]=[CH:15][CH2:16][CH:17]=[CH:18][CH2:19][CH3:20]

参加物

4

反応物 2

HCID 32095,8,11,14,17-Eicosapentaenoic AcidHCID 65578Oxalyl chloride

生成物 1

HCID 540845485,8,11,14,17-Eicosapentaenoyl chloride

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒

実験手順

To a solution of 605 mg of 5,8,11,14,17-eicosapentaenic acid 11 in 6 ml of dry chloroform was added 0.25 ml of oxalyl chloride under argon at room temperature. The mixture was reacted for 2 hours. From the reaction mixture were removed the chloroform and the remaining oxalyl chloride by distillation under reduced pressure to give 5,8,11,14,17-eicosapentaenoyl chloride 12, which was then directly used for the next step.

後処理

  1. customThe mixture was reacted for 2 hours
  2. customFrom the reaction mixture were removed the chloroform
  3. distillationthe remaining oxalyl chloride by distillation under reduced pressure

出典と根拠

ORDレコード
ord-425b402c6c2949728cc352e8914727f2
出典データセット
uspto-grants-2016_04
特許番号
US09321716B1

関連ノート

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