Cyclohexanemethanol → 2-(Cyclohexylmethoxy)pyrimidine

HRID 63351

反応式

HRID 63351 の反応式
[H-].[Na+].Br[C:4]1[N:9]=[CH:8][CH:7]=[CH:6][N:5]=1.[CH:10]1([CH2:16][OH:17])[CH2:15][CH2:14][CH2:13][CH2:12][CH2:11]1>C1COCC1>[CH:10]1([CH2:16][O:17][C:4]2[N:9]=[CH:8][CH:7]=[CH:6][N:5]=2)[CH2:15][CH2:14][CH2:13][CH2:12][CH2:11]1

参加物

5

反応物 3

HCID 7507CyclohexanemethanolHCID 24758Sodium hydrideHCID 783452-Bromopyrimidine

生成物 1

HCID 866946672-(Cyclohexylmethoxy)pyrimidine

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

NaH (1.1 equivalent) is added to an equimolar mixture of 2-bromopyrimidine and cyclohexylmethanol in THF. The reaction mixture is stirred at +60° C. for 18 hours, cooled to room temperature, partitioned between H2O and ethyl acetate. Organic portion is separated, dried over anhydrous Na2SO4 and concentrated under reduced pressure to give 2-(cyclohexylmethoxy)pyrimidine.

後処理

  1. custompartitioned between H2O and ethyl acetate
  2. customOrganic portion is separated
  3. dry with materialdried over anhydrous Na2SO4
  4. concentrationconcentrated under reduced pressure

出典と根拠

ORDレコード
ord-08bcb063c6f745de8323dde4cf803480
出典データセット
uspto-grants-2016_09
特許番号
US09447078B2

関連ノート

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