Diethyl Ether → p-Cyclohexylbenzaldehyde

HRID 636152

反応式

HRID 636152 の反応式
C1OCCOCCOCCOCCOCCOC1.[Cr](Cl)([O-])(=O)=O.[NH+]1C=CC=CC=1.[CH:30]1([C:36]2[CH:43]=[CH:42][C:39]([CH2:40][OH:41])=[CH:38][CH:37]=2)[CH2:35][CH2:34][CH2:33][CH2:32][CH2:31]1.CCOCC>C(Cl)(Cl)Cl>[CH:30]1([C:36]2[CH:37]=[CH:38][C:39]([CH:40]=[O:41])=[CH:42][CH:43]=2)[CH2:31][CH2:32][CH2:33][CH2:34][CH2:35]1

参加物

6

反応物 4

HCID 3283Diethyl EtherHCID 2855718-Crown-6HCID 22492024(4-Cyclohexylphenyl)methanolHCID 178418287HCID 178418287、化合物

生成物 1

HCID 119689p-Cyclohexylbenzaldehyde

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒

実験手順

18-Crown-6 (Aldrich; 4 molar eq.) and pyridinium chlorochromate (Aldrich; 4 molar eq.) were added together in chloroform and stirred for 20 minutes. 4-Cyclohexylbenzylalcohol (from Example D22 below; 1 molar eq.) was added and stirring continued for 3 hours. Ether was added and the mixture filtered through a plug of silica eluting with ether. The solvent was removed via rotary evaporation. The residue was dissolved in ether and washed with water. The organic layer was dried over Na2SO4, filtered, and concentrated.

後処理

  1. stirringstirring
  2. waitcontinued for 3 hours
  3. filtrationthe mixture filtered through a plug of silica eluting with ether
  4. customThe solvent was removed via rotary evaporation
  5. dissolutionThe residue was dissolved in ether
  6. washwashed with water
  7. dry with materialThe organic layer was dried over Na2SO4
  8. filtrationfiltered
  9. concentrationconcentrated

出典と根拠

ORDレコード
ord-ad55b80dab7b4b94806b68929f69acf1
出典データセット
uspto-grants-2001_02
特許番号
US06191166B1

関連ノート

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