Glycolic Acid → Benzyl 2-hydroxyacetate
反応式
[CH2:1](C(O)C(O)=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:13]([OH:17])(=[O:16])[CH2:14][OH:15].C(N(CC1C=CC=CC=1)C(=NC(C)C)O)(C)C>C1COCC1>[C:13]([O:17][CH2:1][C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1)(=[O:16])[CH2:14][OH:15]参加物
5
反応条件
- 温度
- -15 °C
実験手順
Construction of Benzyl-glycolic Acid. Glycolic acid (7.69,100 mmols) is added to N,N'-diisopropylbenzylisourea (23.39,100 mmols) with stirring for 1 hour. The volume is then increased to 200 mL with THF, and the mixture stirred for 48 h at room temperature. After cooling the mixture to -15° C., the diisopropylurea is removed by filtration and the THF evaporated under reduced pressure. The resulting product is pumped under high vacuum for 24 h to give benzyl glycolate which may be used without further purification.
後処理
- stirringthe mixture stirred for 48 h at room temperature
- customthe diisopropylurea is removed by filtration
- customthe THF evaporated under reduced pressure
- waitThe resulting product is pumped under high vacuum for 24 h
出典と根拠
- ORDレコード
- ord-5c317f14cf624df39c513f9852247f2b
- 出典データセット
- uspto-grants-1993_09
- 特許番号
- US05248761
反応ノート
読み込み中…