Pyridine → Methyl N-[[[[[(diethoxyphosphinothioyl)ethylamino]sulfinyl]methylamino]carbonyl]oxy]ethanimidothioate

HRID 647788

反応式

HRID 647788 の反応式
[CH3:1][NH:2][C:3]([O:5][N:6]=[C:7]([S:9][CH3:10])[CH3:8])=[O:4].[S:11](Cl)(Cl)=[O:12].C(N[P:18](=[S:25])([O:22][CH2:23][CH3:24])[O:19][CH2:20][CH3:21])C.[N:26]1C=CC=[CH:28][CH:27]=1>>[CH2:23]([O:22][P:18]([CH2:28][CH2:27][NH:26][S:11]([CH2:1][NH:2][C:3]([O:5][N:6]=[C:7]([S:9][CH3:10])[CH3:8])=[O:4])=[O:12])([O:19][CH2:20][CH3:21])=[S:25])[CH3:24]

参加物

5

反応物 4

HCID 1049PyridineHCID 4109MethomylHCID 24386Thionyl ChlorideHCID 352352O,O-Diethyl N-ethylphosphoramidothioate

生成物 1

HCID 86739073Methyl N-[[[[[(diethoxyphosphinothioyl)ethylamino]sulfinyl]methylamino]carbonyl]oxy]ethanimidothioate

実験手順

Methyl N-[[[[[(diethoxyphosphinothioyl)ethylamino]sulfinyl]methylamino]carbonyl]oxy]ethanimidothioate was prepared by the procedure employed in Example 9, by reacting methyl N-[[(methylamino)carbonyl]oxy]ethanimidothioate (2.43 g, 0.015 mole), thionyl chloride (1.79 g, 0.015 mole), and O,O-diethyl ethylphosphoramidothioate (2.96 g, 0.015 mole) in pyridine (10 ml). Recrystallization from chloroform-hexane afforded 2.95 g of colorless prisms of the formula below, mp 67~68°. ##STR25##

後処理

  1. customRecrystallization from chloroform-hexane

出典と根拠

ORDレコード
ord-3e866b333c244192bacb55b5ff56d21b
出典データセット
uspto-grants-1983_10
特許番号
US04410518

関連ノート

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