1-Iodopropane → 3-Methoxy-2-methyl-4-propoxypyridine

HRID 649208

反応式

HRID 649208 の反応式
[CH3:1][O:2][C:3]1[C:8](=[O:9])[CH:7]=[CH:6][NH:5][C:4]=1[CH3:10].[CH2:11](I)[CH2:12][CH3:13]>CN(C)C=O.C(Cl)(Cl)Cl.[Ag]=O>[CH3:1][O:2][C:3]1[C:4]([CH3:10])=[N:5][CH:6]=[CH:7][C:8]=1[O:9][CH2:11][CH2:12][CH3:13]

参加物

6

反応物 2

HCID 336431-IodopropaneHCID 3234243-Methoxy-2-methyl-1H-pyridin-4-one

生成物 1

HCID 139829483-Methoxy-2-methyl-4-propoxypyridine

試薬・触媒・溶媒 3

HCID 92152Silver(II) oxide触媒HCID 6212Chloroform溶媒HCID 6228Dimethylformamide溶媒

実験手順

3-Methoxy-2-methyl-4(1H)-pyridone(1.39 g) and propyl iodide (2.0 ml) were dissolved in dimethylformamide (20 ml), to which silver oxide (2.31 g) was added in small portions and stirred vigorously at room temperature for 5 hours. The reaction mixture was diluted with chloroform (100 ml), washed with water, dried and evaporated. The residue was purified by flash chromatography (chloroform) on silica gel, to give 3-methoxy-2-methyl-4-propoxypyridine (1.7 g) as a light brown oil.

後処理

  1. additionwas added in small portions
  2. washwashed with water
  3. customdried
  4. customevaporated
  5. customThe residue was purified by flash chromatography (chloroform) on silica gel

出典と根拠

ORDレコード
ord-2a493dc1dce0447e91aa00ee831790d4
出典データセット
uspto-grants-1988_04
特許番号
US04738975

関連ノート

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