Triethylamine → Phosphoramidic dichloride, bis(2-chloroethyl)-

HRID 649337

反応式

HRID 649337 の反応式
[P:1]([Cl:5])(Cl)([Cl:3])=[O:2].[Cl:6][CH2:7][CH2:8][NH:9][CH2:10][CH2:11][Cl:12].C(N(CC)CC)C.Cl.C(N(CC)CC)C>C1COCC1>[Cl:6][CH2:7][CH2:8][N:9]([CH2:10][CH2:11][Cl:12])[P:1]([Cl:5])([Cl:3])=[O:2]

参加物

6

反応物 4

HCID 8471TriethylamineHCID 9533Bis(2-chloroethyl)amineHCID 11130Triethylamine hydrochlorideHCID 24813Phosphorus oxychloride

生成物 1

HCID 96271Phosphoramidic dichloride, bis(2-chloroethyl)-

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒2 回

実験手順

Phosphorous oxychloride (0.15 mol) in 100 ml. THF are mixed dropwise at 10° C. with bis-chloroethylamine (0.1 mol) in 100 ml. THF and triethylamine (0.15 mol). After ending of the reaction (TLC verification), triethylamine hydrochloride is filtered off and the filtrate, after the addition of 50 ml. toluene, evaporated. The oily residue is immediately further reacted.

後処理

  1. filtrationis filtered off
  2. additionthe filtrate, after the addition of 50 ml
  3. customtoluene, evaporated
  4. customThe oily residue is immediately further reacted

出典と根拠

ORDレコード
ord-c0af85cf54a442ee855b99cb32b2c48a
出典データセット
uspto-grants-1988_04
特許番号
US04739095

関連ノート

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