Methanol → Methyl isobutyrate

HRID 65140

反応式

HRID 65140 の反応式
F[C:2](F)(F)[C:3]1[CH:8]=CC=C[C:4]=1P([C:16]1[CH:21]=CC=CC=1)C1C=CC=CC=1.C[OH:25].[O:26]1[CH2:31][CH2:30][O:29][CH2:28][CH2:27]1>[Pd](Cl)Cl>[C:4]([O:26][CH3:27])(=[O:25])[CH:3]([CH3:8])[CH3:2].[C:30]([O:29][CH3:28])(=[O:25])[CH2:31][CH2:21][CH3:16]

参加物

6

反応物 3

HCID 887MethanolHCID 312751,4-DioxaneHCID 303893Diphenyl[2-(trifluoromethyl)phenyl]phosphane

生成物 2

HCID 11039Methyl isobutyrateHCID 12180Methyl butyrate

試薬・触媒・溶媒 1

HCID 24290Palladium Chloride触媒

反応条件

温度
120 °C

実験手順

The autoclave was charged with 0.3 gms of palladium chloride, 5 gms o-trifluoromethylphenyldiphenylphosphine, 10 mls of methanol and 50 ml of p-dioxane. After flushing with nitrogen, the autoclave was pressurized with carbon monoxide to 800 psig and heated to 120 degrees C. with stirring. 10 gms of liquid propylene was added and the reaction continued at 120° C. and 100 psig for 3 hours. The autoclave was then cooled and the reaction fluid analyzed by gas chromatography. A methyl isobutyrate:methyl n-butyrate ratio of 7.1:1 was obtained.

後処理

  1. customAfter flushing with nitrogen
  2. addition10 gms of liquid propylene was added
  3. customcontinued at 120° C.
  4. temperatureThe autoclave was then cooled

出典と根拠

ORDレコード
ord-e5490df9d8cf467daca53ea437840a1c
出典データセット
uspto-grants-1986_09
特許番号
US04612390

関連ノート

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