Iodoethane → N-Ethylphenothiazine
反応式
[CH:1]1[C:14]2[NH:13][C:12]3[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=3)[S:6][C:5]=2[CH:4]=[CH:3][CH:2]=1.I[CH2:16][CH3:17].[OH-].[K+]>S([O-])(O)(=O)=O.C([N+](CCCC)(CCCC)CCCC)CCC.C1(C)C=CC=CC=1>[CH2:16]([N:13]1[C:14]2[CH:1]=[CH:2][CH:3]=[CH:4][C:5]=2[S:6][C:7]2[C:12]1=[CH:11][CH:10]=[CH:9][CH:8]=2)[CH3:17]参加物
6
実験手順
A mixture of 10 g (0.05 mol) of phenothiazine, 11.7 g (0.075 mol) of iodoethane, 4.2 g (0.075 mol) of potassium hydroxide and 0.25 g of tetra-n-butylammonium hydrogen sulfate in 200 ml of dry toluene was refluxed for 24 hours. After cooling, the reaction mixture was filtered, and the solvent was evaporated. The product was crystallized from methanol. The yield of 10-ethylphenothiazine (C14H13NS, FW=227.33) was 90%.
後処理
- temperaturewas refluxed for 24 hours
- temperatureAfter cooling
- filtrationthe reaction mixture was filtered
- customthe solvent was evaporated
- customThe product was crystallized from methanol
出典と根拠
- ORDレコード
- ord-625c6e1d30dd4d0a9f0e4279bcd0f5ff
- 出典データセット
- uspto-grants-2006_08
- 特許番号
- US07083884B2
反応ノート
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