Diethyl Ether → 7-Chloro-1-methyllepidinium iodide

HRID 6602

反応式

HRID 6602 の反応式
[Cl:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6]([CH3:12])=[CH:7][CH:8]=[N:9]2)=[CH:4][CH:3]=1.C[I:14].[CH2:15](OCC)C>CC#N>[I-:14].[Cl:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6]([CH3:12])=[CH:7][CH:8]=[N+:9]2[CH3:15])=[CH:4][CH:3]=1

参加物

5

反応物 3

HCID 3283Diethyl EtherHCID 6328Methyl iodideHCID 1704377-Chloro-4-methylquinoline

生成物 1

HCID 220163717-Chloro-1-methyllepidinium iodide

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

A portion of the 7-chlorolepidine (80 mg) prepared as above was methylated by heating with CH3I (0.5 ml) in CH3CN (1 ml) at reflux for two hours. The mixture was treated with diethyl ether, followed by centrifugation, to give a yellow powder.

後処理

  1. temperatureat reflux for two hours
  2. customto give a yellow powder

出典と根拠

ORDレコード
ord-6a873647e2b44ce99055068705e47796
出典データセット
uspto-grants-2006_08
特許番号
US07083982B2

関連ノート

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