2-(4-Nitrophenyl)propionic acid → 4-Aminohydratropic acid
反応式
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([CH:10]([CH3:14])[C:11]([OH:13])=[O:12])=[CH:6][CH:5]=1)([O-])=O>C1COCC1.CCO.[Pd]>[NH2:1][C:4]1[CH:5]=[CH:6][C:7]([CH:10]([CH3:14])[C:11]([OH:13])=[O:12])=[CH:8][CH:9]=1参加物
5
実験手順
A mixture of 1 (6.7 g, 1 mmol) in THF (100 ml) and EtOH (100 ml) is slowly added 10% Pd/C (680 mg) at room temperature. The reaction mixture is hydrogenated for 24 h with H2 balloon at room temperature. The mixture is filtered through celite pad and washed with EtOH. The filtrate is concentrated in vacuo.
後処理
- customat room temperature
- filtrationThe mixture is filtered through celite pad
- washwashed with EtOH
- concentrationThe filtrate is concentrated in vacuo
出典と根拠
- ORDレコード
- ord-fdc8fedb933d421686298bc443ce1c81
- 出典データセット
- uspto-grants-2011_12
- 特許番号
- US08084484B2
反応ノート
読み込み中…