2-(4-Nitrophenyl)propionic acid → 4-Aminohydratropic acid

HRID 660342

反応式

HRID 660342 の反応式
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([CH:10]([CH3:14])[C:11]([OH:13])=[O:12])=[CH:6][CH:5]=1)([O-])=O>C1COCC1.CCO.[Pd]>[NH2:1][C:4]1[CH:5]=[CH:6][C:7]([CH:10]([CH3:14])[C:11]([OH:13])=[O:12])=[CH:8][CH:9]=1

参加物

5

反応物 1

HCID 892442-(4-Nitrophenyl)propionic acid

生成物 1

HCID 430264-Aminohydratropic acid

試薬・触媒・溶媒 3

HCID 23938Palladium触媒HCID 702Ethanol溶媒HCID 8028Tetrahydrofuran溶媒

実験手順

A mixture of 1 (6.7 g, 1 mmol) in THF (100 ml) and EtOH (100 ml) is slowly added 10% Pd/C (680 mg) at room temperature. The reaction mixture is hydrogenated for 24 h with H2 balloon at room temperature. The mixture is filtered through celite pad and washed with EtOH. The filtrate is concentrated in vacuo.

後処理

  1. customat room temperature
  2. filtrationThe mixture is filtered through celite pad
  3. washwashed with EtOH
  4. concentrationThe filtrate is concentrated in vacuo

出典と根拠

ORDレコード
ord-fdc8fedb933d421686298bc443ce1c81
出典データセット
uspto-grants-2011_12
特許番号
US08084484B2

関連ノート

読み込み中…