Azobisisobutyronitrile → Bromo-(2-iodophenyl)-acetic Acid Methyl Ester

HRID 660568

反応式

HRID 660568 の反応式
[CH3:1][O:2][C:3](=[O:12])[CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[I:11].C1C(=O)N([Br:20])C(=O)C1.CC(N=NC(C#N)(C)C)(C#N)C>C(Cl)(Cl)(Cl)Cl>[CH3:1][O:2][C:3](=[O:12])[CH:4]([Br:20])[C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[I:11]

参加物

5

反応物 3

HCID 6547AzobisisobutyronitrileHCID 67184N-bromobutanimideHCID 640185Methyl 2-(2-iodophenyl)acetate

生成物 1

HCID 86632576Bromo-(2-iodophenyl)-acetic Acid Methyl Ester

試薬・触媒・溶媒 1

HCID 5943Carbon Tetrachloride溶媒

実験手順

A mixture of (2-iodophenyl)-acetic acid methyl ester (14.5 g, 52.5 mmol), NBS (18.7 g, 105 mmol) and AIBN (1.72 g, 10.5 mmol) in CCl4 (300 mL) is refluxed for 10 h. The mixture is cooled to RT and the precipitate filtered. The filtrate is evaporated to give the title compound.

後処理

  1. temperatureis refluxed for 10 h
  2. filtrationthe precipitate filtered
  3. customThe filtrate is evaporated

出典と根拠

ORDレコード
ord-db93df6fcc214a318294e7c39ea96e68
出典データセット
uspto-grants-2011_12
特許番号
US08084448B2

関連ノート

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