Benzyl Alcohol → 2-Amino-3-morpholino-5-benzyloxypyrazine

HRID 66759

反応式

HRID 66759 の反応式
[H-].[Na+].[CH2:3]([OH:10])[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.[NH2:11][C:12]1[C:17]([N:18]2[CH2:23][CH2:22][O:21][CH2:20][CH2:19]2)=[N:16][C:15](Br)=[CH:14][N:13]=1>C1C=CC=CC=1>[NH2:11][C:12]1[C:17]([N:18]2[CH2:19][CH2:20][O:21][CH2:22][CH2:23]2)=[N:16][C:15]([O:10][CH2:3][C:4]2[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=2)=[CH:14][N:13]=1

参加物

5

反応物 3

HCID 244Benzyl AlcoholHCID 24758Sodium hydrideHCID 167404415-Bromo-3-morpholinopyrazin-2-amine

生成物 1

HCID 205289342-Amino-3-morpholino-5-benzyloxypyrazine

試薬・触媒・溶媒 1

HCID 241Benzene溶媒2 回

実験手順

Sodium hydride (0.1 mole) is added to benzyl alcohol (0.1 mole) in 100 ml. dry benzene and the mixture is refluxed one to two hours. The cooled solution is treated with 0.1 mole of 2-amino-3-morpholino-5-bromopyrazine in 100 ml. of benzene and the resulting mixture refluxed for 20-60 hours whereupon it is cooled, washed with water, dried and evaporated to give 2-amino-3-morpholino-5-benzyloxypyrazine.

後処理

  1. temperatureis cooled
  2. washwashed with water
  3. customdried
  4. customevaporated

出典と根拠

ORDレコード
ord-211a8934f2b34af3a63246b2895799df
出典データセット
uspto-grants-1982_08
特許番号
US04343802

関連ノート

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