3-Chlorobenzoic Acid → Thionyl Chloride

HRID 67869

反応式

HRID 67869 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][CH:10]=1)[C:5]([OH:7])=O.[S:11]([Cl:14])([Cl:13])=[O:12].ClC1C=C(C=CC=1)C(Cl)=O.[NH2:25][C:26]([CH3:30])([CH3:29])[CH2:27]O>>[Cl:1][C:2]1[CH:3]=[C:4]([C:5]2[O:7][CH2:27][C:26]([CH3:30])([CH3:29])[N:25]=2)[CH:8]=[CH:9][CH:10]=1.[S:11]([Cl:14])([Cl:13])=[O:12]

参加物

6

反応物 4

HCID 4473-Chlorobenzoic AcidHCID 118072-Amino-2-methyl-1-propanolHCID 24386Thionyl ChlorideHCID 69252Benzoyl chloride, 3-chloro-

生成物 2

HCID 24386Thionyl ChlorideHCID 10798476Oxazole, 2-(3-chlorophenyl)-4,5-dihydro-4,4-dimethyl-

実験手順

2-(3-Chlorophenyl)-4,4-dimethyl-2-oxazoline was prepared from 3-chlorobenzoic acid by reaction with thionyl chloride to give 3-chlorobenzoylchloride, reaction of this acid chloride with 2-amino-2-methylpropanol to give the amide and cyclization of the amide with thionyl chloride followed by neutralization with dilute sodium hydroxide to give 2-(3-chlorophenyl)-4,4-dimethyl-2-oxazoline.

後処理

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出典と根拠

ORDレコード
ord-fc3e60aa365a45c59398a6faf9402290
出典データセット
uspto-grants-1982_08
特許番号
US04347177

関連ノート

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