6-Phenylnicotinic acid → 6-phenylnicotinic acid N'-(4-methoxybutyryl)hydrazide

HRID 6926

反応式

HRID 6926 の反応式
[C:1]1([C:7]2[CH:15]=[CH:14][C:10]([C:11]([OH:13])=O)=[CH:9][N:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Cl.[CH3:17][O:18][CH2:19][CH2:20][CH2:21][C:22]([NH:24][NH2:25])=[O:23].Cl.C(N=C=NCCCN(C)C)C>N1C=CC=CC=1>[CH3:17][O:18][CH2:19][CH2:20][CH2:21][C:22]([NH:24][NH:25][C:11](=[O:13])[C:10]1[CH:14]=[CH:15][C:7]([C:1]2[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=2)=[N:8][CH:9]=1)=[O:23]

参加物

5

反応物 3

HCID 1201186-Phenylnicotinic acidHCID 27239391,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochlorideHCID 865902274-Methoxybutyric acid hydrazide hydrochloride salt

生成物 1

HCID 695844476-phenylnicotinic acid N'-(4-methoxybutyryl)hydrazide収率 65.3%

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

反応条件

温度
60 °C

実験手順

6-Phenylnicotinic acid (5.90 g) was dissolved in pyridine (150 ml), followed by addition of 4-methoxybutyric acid hydrazide hydrochloride salt (5.99 g) and 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride salt (8.51 g), and stirred at 60° C. for 10 hours. After the reaction solution was cooled to ambient temperature, the solvent was evaporated under reduced pressure. The resulting residue was washed with water, to afford 6-phenylnicotinic acid N′-(4-methoxybutyryl)hydrazide as pale yellow solid (6.06 g, 65%). The physico-chemical values are as follows.

後処理

  1. temperatureAfter the reaction solution was cooled to ambient temperature
  2. customthe solvent was evaporated under reduced pressure
  3. washThe resulting residue was washed with water

出典と根拠

ORDレコード
ord-e17521f35c844b38b7cd816a96b56009
出典データセット
uspto-grants-2006_08
特許番号
US07084164B2

関連ノート

読み込み中…