Diisopropylethylamine → N-[[[1-Azabicyclo[2.2.2]octan-3-yl]amino]carbonyl]-2-thiophenecarboxamide

HRID 703416

反応式

HRID 703416 の反応式
Cl.Cl.[NH2:3][CH:4]1[CH:9]2[CH2:10][CH2:11][N:6]([CH2:7][CH2:8]2)[CH2:5]1.[S:12]1[CH:16]=[CH:15][CH:14]=[C:13]1[C:17]([NH:19][C:20](N)=[O:21])=[O:18].C(N(C(C)C)CC)(C)C.C([O-])(=O)/C=C\C([O-])=O>N1C=CC=CC=1>[N:6]12[CH2:11][CH2:10][CH:9]([CH2:8][CH2:7]1)[CH:4]([NH:3][C:20]([NH:19][C:17]([C:13]1[S:12][CH:16]=[CH:15][CH:14]=1)=[O:18])=[O:21])[CH2:5]2

参加物

6

反応物 4

HCID 81531DiisopropylethylamineHCID 197853Quinuclidine, 3-amino-, dihydrochlorideHCID 395032N-(Aminocarbonyl)-2-thiophenecarboxamideHCID 5288227Maleate(2-)

生成物 1

HCID 15616403N-[[[1-Azabicyclo[2.2.2]octan-3-yl]amino]carbonyl]-2-thiophenecarboxamide

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

実験手順

The above compound was prepared, following the procedure of Example 14b, from 3-aminoquinuclidine dihydrochloride (1.0 g, 5 mmol), 2-thienoylurea (0.85 g, 5 mmol) and diisopropylethylamine (1.3 g, 10 mmol) in pyridine (20 ml). The product (0.79 g) was converted to hydrochloride half hydrate, mp 232°-233° C.

後処理

  1. customThe above compound was prepared

出典と根拠

ORDレコード
ord-f5c9b0a985694562aec02036d1803a0f
出典データセット
uspto-grants-1991_01
特許番号
US04983600

関連ノート

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