Sodium Hydroxide → 3-Cyclohexyl-3-methylaminomethyloxetane

反応式

[CH:1]1([C:7]2([CH:11]=O)[CH2:10][O:9][CH2:8]2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.C([O-])(=O)C.[Na+].Cl.CN.[C:21]([BH3-])#[N:22].[Na+].[OH-].[Na+]>CO>[CH:1]1([C:7]2([CH2:11][NH:22][CH3:21])[CH2:10][O:9][CH2:8]2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

参加物

反応物 5

HCID 14798Sodium Hydroxide

HCID 517045Sodium Acetate

HCID 5003444Sodium cyanoborohydride

HCID 6364545Methylamine hydrochloride

HCID 200755923-Cyclohexyl-3-formyloxetane

生成物 1

HCID 200755603-Cyclohexyl-3-methylaminomethyloxetane

試薬・触媒・溶媒 1

実験手順

3-Cyclohexyl-3-formyloxetane (1.7 g) was dissolved in methanol (10 ml) at 25° C. In succession, anhydrous sodium acetate (3.3 g), methylamine hydrochloride (3.4 g) and sodium cyanoborohydride (630 mg) were added, followed by a further volume of methanol (30 ml). The mixture was stirred overnight and then basified with sodium hydroxide solution (1M, 22 ml) to pH9. Ether extraction, washing and drying, followed by evaporation gave 3-cyclohexyl-3-methylaminomethyloxetane as a colourless oil.