Trifluoroacetic acid → 6-Iodo-2-methoxypyridin-3-ol
反応式
C([SiH](C(C)C)C(C)C)(C)C.FC(F)(F)C(O)=O.[I:18][C:19]1[N:24]=[C:23]([O:25][CH3:26])[C:22]([O:27]CC2C=CC(OC)=CC=2)=[CH:21][CH:20]=1>C(Cl)(Cl)Cl>[I:18][C:19]1[N:24]=[C:23]([O:25][CH3:26])[C:22]([OH:27])=[CH:21][CH:20]=1参加物
5
反応条件
- 温度
- 0 °C
実験手順
Triisopropylsilane (2.1 g) and trifluoroacetic acid (4.0 mL) were added to a solution of 6-iodo-2-methoxy-3-[(4-methoxybenzyl)oxy]pyridine (1 g) in chloroform (10 mL), and the mixture was stirred at 0° C. for one hour. The solvent was evaporated from the reaction solution under reduced pressure. The residue was purified by silica gel column chromatography (hexane:ethyl acetate=90:10→50:50) to give the title compound as a colorless powder (604 mg, 96%).
後処理
- customThe solvent was evaporated from the reaction solution under reduced pressure
- customThe residue was purified by silica gel column chromatography (hexane:ethyl acetate=90:10→50:50)
出典と根拠
- ORDレコード
- ord-183bad4a36804068b6fe87ce50790428
- 出典データセット
- uspto-grants-2014_09
- 特許番号
- US08822503B2
反応ノート
読み込み中…