[OH:1][C:2]([C:4]([F:7])([F:6])[F:5])=[O:3].OC(C(F)(F)F)=O.[CH:15]12[O:22][CH:19]([CH2:20][CH2:21]1)[CH2:18][N:17]([C:23]1[N:28]=[C:27]([N:29]3[CH2:34][CH2:33][NH:32][CH2:31][CH2:30]3)[N:26]=[C:25]([C:35]3[CH:40]=[CH:39][C:38]([NH:41][C:42]([NH:44][C:45]4[CH:50]=[CH:49][N:48]=[CH:47][CH:46]=4)=[O:43])=[CH:37][CH:36]=3)[N:24]=1)[CH2:16]2.C(N(CC)CC)C.Cl[C:59]([O:61][CH3:62])=[O:60]>ClCCl.O1CCCC1>[CH:19]12[O:22][CH:15]([CH2:21][CH2:20]1)[CH2:16][N:17]([C:23]1[N:24]=[C:25]([C:35]3[CH:36]=[CH:37][C:38]([NH:41][C:42](=[O:43])[NH:44][C:45]4[CH:46]=[CH:47][N:48]=[CH:49][CH:50]=4)=[CH:39][CH:40]=3)[N:26]=[C:27]([N:29]3[CH2:34][CH2:33][N:32]([C:59]([O:61][CH3:62])=[O:60])[CH2:31][CH2:30]3)[N:28]=1)[CH2:18]2.[C:2]([OH:3])([C:4]([F:7])([F:6])[F:5])=[O:1]1-(4-(4-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)-6-(piperazin-1-yl)-1,3,5-triazin-2-yl)phenyl)-3-(pyridin-4-yl)urea-2TFA (75 mg) in dichloromethane (2 mL), tetrahydrofuran (2 mL), and triethylamine (1 mL) was treated with methyl chloroformate (0.10 mL). The mixture was concentrated to dryness and purified on RP-HPLC to give the title compound as its TFA salt. MS (ES+) 546.3 (M+H)+
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