Acetic Acid → 2-(Methylthio)-1H-pyrimidin-4-one

HRID 714773

反応式

HRID 714773 の反応式
[S:1]=[C:2]1[NH:7][C:6](=[O:8])[CH:5]=[CH:4][NH:3]1.[OH-].[Na+].[C:11](O)(=O)C>O.IC>[CH3:11][S:1][C:2]1[NH:7][C:6](=[O:8])[CH:5]=[CH:4][N:3]=1

参加物

6

反応物 3

HCID 176Acetic AcidHCID 14798Sodium HydroxideHCID 1269845Thiouracil

生成物 1

HCID 798232-(Methylthio)-1H-pyrimidin-4-one

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 6328Methyl iodide溶媒

実験手順

To 2-thioxo-2,3-dihydropyrimidin-4(1H)-one (21 g) was added dropwise a solution of sodium hydroxide (13 g) in water (120 mL), iodomethane (11.5 mL) was added thereto, and the mixture was stirred overnight at room temperature. To the reaction mixture was added acetic acid (9.5 mL), and the resulting solid was collected by filtration. The obtained solid was washed with cold water to give the title compound (24 g).

後処理

  1. additionwas added
  2. filtrationthe resulting solid was collected by filtration
  3. washThe obtained solid was washed with cold water

出典と根拠

ORDレコード
ord-34b66474704041fea99a3a36c45d8f29
出典データセット
uspto-grants-2015_11
特許番号
US09187453B2

関連ノート

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