Methyl iodide → 4-Fluoro-N-methyl-N-[2-(5-methyl-furan-2-yl)-ethyl]-benzamide

HRID 723672

反応式

HRID 723672 の反応式
[H-].[Na+].[F:3][C:4]1[CH:20]=[CH:19][C:7]([C:8]([NH:10][CH2:11][CH2:12][C:13]2[O:14][C:15]([CH3:18])=[CH:16][CH:17]=2)=[O:9])=[CH:6][CH:5]=1.I[CH3:22]>C1COCC1>[F:3][C:4]1[CH:5]=[CH:6][C:7]([C:8]([N:10]([CH3:22])[CH2:11][CH2:12][C:13]2[O:14][C:15]([CH3:18])=[CH:16][CH:17]=2)=[O:9])=[CH:19][CH:20]=1

参加物

5

反応物 3

HCID 6328Methyl iodideHCID 24758Sodium hydrideHCID 218748464-Fluoro-N-[2-(5-methyl-2-furanyl)ethyl]benzamide

生成物 1

HCID 218749624-Fluoro-N-methyl-N-[2-(5-methyl-furan-2-yl)-ethyl]-benzamide収率 84%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

NaH (60% dispersion in oil, 65 mg, 1.63 mmol) was added portionwise to a solution of 4-fluoro-N-[2-(5-methyl-2-furanyl)ethyl]benzamide (269 mg, 1.09 mmol, 237A) in THF (5 mL). After gas evolution ceased, iodomethane (0.14 mL, 2.18 mmol) was added drop-wise. Once HPLC analysis showed the reaction to be 50% complete, the mixture was concentrated under reduced pressure and resubjected to the above conditions. After all the starting material was consumed, H2O was added and the resulting mixture was extracted with EtOAc (2×5 mL). The combined organic layers were dried over Na2SO4 and concentrated under reduced pressure. Purification by flash chromatography on silica gel eluting with 20% acetone/CHCl3 gave 238 mg (84%) of compound 425A. HPLC: 98% at 2.94 min (retention time) (Phenomenex-prime S5-C18 column 4.6×50 mm eluting with 10–90% aqueous methanol over 4 minutes containing 0.2% phosphoric acid, 4 mL/min, monitoring at 220 nm). MS (ES): m/z [M+H]=262.38.

後処理

  1. customthe reaction
  2. concentrationthe mixture was concentrated under reduced pressure
  3. customAfter all the starting material was consumed
  4. additionH2O was added
  5. extractionthe resulting mixture was extracted with EtOAc (2×5 mL)
  6. dry with materialThe combined organic layers were dried over Na2SO4
  7. concentrationconcentrated under reduced pressure
  8. customPurification by flash chromatography on silica gel eluting with 20% acetone/CHCl3

出典と根拠

ORDレコード
ord-b3934f16316f48639f3ea9f7a704bd0a
出典データセット
uspto-grants-2006_11
特許番号
US07141578B2

関連ノート

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