Tetrahydrofuran → 4-(Hydroxymethyl)-1-phenylpyrrolidin-2-one
反応式
C(N1C=CN=C1)(N1C=CN=C1)=O.C1COCC1.[O:18]=[C:19]1[N:23]([C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)[CH2:22][CH:21]([C:30](O)=[O:31])[CH2:20]1.[BH4-].[Na+]>O>[OH:31][CH2:30][CH:21]1[CH2:22][N:23]([C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)[C:19](=[O:18])[CH2:20]1参加物
6
実験手順
1,1′-Carbonylbisimidazole was added to a THF solution of 5-oxo-1-phenylpyrrolidine-3-carboxylic acid and stirred at room temperature for 1.5Hours. Successively sodium borohydride and 2.0 ml of water were added thereto and stirred at room temperature for 1Hour. Thereafter, its work-up and purification were carried out in the standard method to obtain 4-(hydroxymethyl)-1-phenylpyrrolidin-2-one. EP: 192.
後処理
- stirringstirred at room temperature for 1Hour
- customThereafter, its work-up and purification
出典と根拠
- ORDレコード
- ord-485876b4307e437ebc8428f659494de1
- 出典データセット
- uspto-grants-2009_09
- 特許番号
- US07585886B2
反応ノート
読み込み中…