Hydrochloric Acid → 2-Chloro-4-nitrobenzyl alcohol

HRID 735052ノート

反応式

HRID 735052 の反応式
C(N1C=CN=C1)(N1C=CN=C1)=O.[Cl:13][C:14]1[CH:22]=[C:21]([N+:23]([O-:25])=[O:24])[CH:20]=[CH:19][C:15]=1[C:16](O)=[O:17].[BH4-].[Na+].Cl>C1COCC1.O>[Cl:13][C:14]1[CH:22]=[C:21]([N+:23]([O-:25])=[O:24])[CH:20]=[CH:19][C:15]=1[CH2:16][OH:17]

参加物

7

反応物 4

HCID 313Hydrochloric AcidHCID 74482-Chloro-4-nitrobenzoic acidHCID 682631,1'-CarbonyldiimidazoleHCID 4311764Sodium borohydride

生成物 1

HCID 1041472-Chloro-4-nitrobenzyl alcohol

試薬・触媒・溶媒 2

HCID 962Water溶媒2 回HCID 8028Tetrahydrofuran溶媒

反応条件

温度
35 °C

実験手順

35.9 g (0.22 mol) of 1,1′-carbonyldiimidazole is slowly added to a solution of 41.1 g (0.2 mol) of 2-chloro-4-nitrobenzoic acid in 400 mL of THF. The reaction mixture is stirred for 1.5 hours at 35° C. Then the green reaction mixture is cooled down using ice and at maximum 20° C. combined dropwise with a solution of 26.5 g (0.7 mol) of sodium borohydride in 400 mL of water. After 1.5 hours stirring, the reaction mixture is diluted with 200 mL of water and then neutralized with 250 mL of semiconcentrated hydrochloric acid. It is stirred for 1 hour, then extracted twice with ethyl acetate and the organic phase is dried over sodium sulfate. The desiccant is filtered off and the solvent is evaporated down. The residue is crystallized with petroleum ether, suction filtered, and dried at 50° C. in the drying chamber. Yield: 37.66 g (100% of theory); melting point: 62° C.-64° C.; C7H6ClNO3 (M=187.58); calc.: molecular ion peak (M+H)+: 187/189 (Cl); found: molecular ion peak (M+H)+: 187/189 (Cl); Rf value: 0.70 (silica gel, dichloromethane/methanol (90:10)).

後処理

  1. temperatureThen the green reaction mixture is cooled down
  2. customat maximum 20° C.
  3. stirringAfter 1.5 hours stirring
  4. stirringIt is stirred for 1 hour
  5. extractionextracted twice with ethyl acetate
  6. dry with materialthe organic phase is dried over sodium sulfate
  7. filtrationThe desiccant is filtered off
  8. customthe solvent is evaporated down
  9. customThe residue is crystallized with petroleum ether, suction
  10. filtrationfiltered
  11. customdried at 50° C. in the drying chamber

出典と根拠

ORDレコード
ord-2f5ed1b6cb3346438530c7a292e2b0e9
出典データセット
uspto-grants-2009_09
特許番号
US07592373B2

反応ノート

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