2-Tert-Butylphenol → 4-Bromo-2-tert-butylphenol

HRID 73996

反応式

HRID 73996 の反応式
[C:1]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[OH:11])([CH3:4])([CH3:3])[CH3:2].C1C(=O)N([Br:19])C(=O)C1>CC#N>[C:1]([C:5]1[CH:10]=[C:9]([Br:19])[CH:8]=[CH:7][C:6]=1[OH:11])([CH3:4])([CH3:2])[CH3:3]

参加物

4

反応物 2

HCID 69232-Tert-ButylphenolHCID 67184N-bromobutanimide

生成物 1

HCID 970684-Bromo-2-tert-butylphenol収率 99.3%

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

To a solution of 2-tert-butylphenol (250 g, 1.67 mol) in CH3CN (1500 mL) was added NBS (300 g, 1.67 mol) at room temperature. After addition, the mixture was stirred at room temperature overnight and then the solvent was removed. Petroleum ether (1000 mL) was added, and the resulting white precipitate was filtered off. The filtrate was concentrated under reduced pressure to give the crude 2-tert-butyl-4-bromophenol (380 g), which was used without further purification.

後処理

  1. additionAfter addition
  2. customthe solvent was removed
  3. additionPetroleum ether (1000 mL) was added
  4. filtrationthe resulting white precipitate was filtered off
  5. concentrationThe filtrate was concentrated under reduced pressure

出典と根拠

ORDレコード
ord-97ca45fe2d5043acb3e89dba7009a4e9
出典データセット
uspto-grants-2014_09
特許番号
US08829204B2

関連ノート

読み込み中…