Sodium Hydroxide → 1-[3-(4-tert-Butylphenyl)-2-methylpropyl]-4-methylpiperazine

HRID 745485

反応式

HRID 745485 の反応式
[C:1]([C:5]1[CH:10]=[CH:9][C:8]([CH2:11][CH:12]([CH3:15])[CH2:13]Cl)=[CH:7][CH:6]=1)([CH3:4])([CH3:3])[CH3:2].[CH3:16][N:17]1[CH2:22][CH2:21][NH:20][CH2:19][CH2:18]1.[OH-].[Na+]>CCOCC>[CH3:16][N:17]1[CH2:22][CH2:21][N:20]([CH2:13][CH:12]([CH3:15])[CH2:11][C:8]2[CH:9]=[CH:10][C:5]([C:1]([CH3:4])([CH3:3])[CH3:2])=[CH:6][CH:7]=2)[CH2:19][CH2:18]1

参加物

5

反応物 3

HCID 14798Sodium HydroxideHCID 531671-MethylpiperazineHCID 132518171-tert-Butyl-4-(3-chloro-2-methylpropyl)benzene

生成物 1

HCID 132519811-[3-(4-tert-Butylphenyl)-2-methylpropyl]-4-methylpiperazine収率 93.6%

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒

実験手順

533 g of 3-(4-tert.butylphenyl)-2-methylpropyl chloride and 714 g of 4-methylpiperazine were stirred for 7 hours at 140° C. and then cooled to +10° C. in an ice bath, and 400 ml of 50% strength sodium hyroxide solution were added slowly, followed by the addition of 500 ml of ether. The organic phase was separated off, dried over sodium hydroxide and distilled to give 640 g of 1-methyl-4-[3-(4-tert.-butylphenyl)-2-methylpropyl]-piperazine of boiling point 135°-140° C./0.3 mbar.

後処理

  1. temperaturecooled to +10° C. in an ice bath
  2. customThe organic phase was separated off
  3. dry with materialdried over sodium hydroxide
  4. distillationdistilled

出典と根拠

ORDレコード
ord-8bdee9547f6c4f59aa42d2195697c970
出典データセット
uspto-grants-1986_07
特許番号
US04599335

関連ノート

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