Sodium Thiosulfate → 6-(5-Benzylhexahydropyrrolo[3,4-c]pyrrol-2-yl)-2-(4-fluorophenyl)-3-iodo-7,8-dimethylimidazo[1,2-b]pyridazine

HRID 80724ノート

反応式

HRID 80724 の反応式
[CH2:1]([N:8]1[CH2:12][CH:11]2[CH2:13][N:14]([C:16]3[C:17]([CH3:33])=[C:18]([CH3:32])[C:19]4[N:20]([CH:22]=[C:23]([C:25]5[CH:30]=[CH:29][C:28]([F:31])=[CH:27][CH:26]=5)[N:24]=4)[N:21]=3)[CH2:15][CH:10]2[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[I:34]Cl.C(=O)([O-])O.[Na+].S([O-])([O-])(=O)=S.[Na+].[Na+]>C(Cl)(Cl)Cl.CO>[CH2:1]([N:8]1[CH2:12][CH:11]2[CH2:13][N:14]([C:16]3[C:17]([CH3:33])=[C:18]([CH3:32])[C:19]4[N:20]([C:22]([I:34])=[C:23]([C:25]5[CH:26]=[CH:27][C:28]([F:31])=[CH:29][CH:30]=5)[N:24]=4)[N:21]=3)[CH2:15][CH:10]2[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

7

反応物 4

HCID 24477Sodium ThiosulfateHCID 24640Iodine chlorideHCID 516892Sodium BicarbonateHCID 594069716-(5-Benzylhexahydropyrrolo[3,4-c]pyrrol-2-yl)-2-(4-fluorophenyl)-7,8-dimethylimidazo[1,2-b]pyridazine

生成物 1

HCID 594069656-(5-Benzylhexahydropyrrolo[3,4-c]pyrrol-2-yl)-2-(4-fluorophenyl)-3-iodo-7,8-dimethylimidazo[1,2-b]pyridazine

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 6212Chloroform溶媒

実験手順

To a solution, cooled to 0° C., of 3.2 g (7.3 mmol) of 6-(5-benzylhexahydropyrrolo[3,4-c]pyrrol-2-yl)-2-(4-fluorophenyl)-7,8-dimethylimidazo[1,2-b]pyridazine in 20 mL of chloroform is added dropwise a solution of 1.8 g (11 mmol) of iodine monochloride in 3 mL of methanol and the medium is stirred for one hour at room temperature. The medium is then basified by addition of aqueous sodium hydrogen carbonate solution and 5% sodium thiosulfate solution is then added until the medium has decolorized.

後処理

  1. additionis then added until the medium

出典と根拠

ORDレコード
ord-1a0e814282a2471781ff4d1d62d1d268
出典データセット
uspto-grants-2014_09
特許番号
US08846676B2

反応ノート

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