L-Tryptophan → Tryptophan butyl ester

HRID 80946

反応式

HRID 80946 の反応式
[NH2:1][C@H:2]([C:13]([OH:15])=[O:14])[CH2:3][C:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[NH:6][CH:5]=1.S(Cl)(Cl)=O>C(O)CCC>[CH2:13]([O:14][C:13](=[O:15])[C@H:2]([CH2:3][C:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[NH:6][CH:5]=1)[NH2:1])[CH2:2][CH2:3][CH3:4]

参加物

4

反応物 2

HCID 6305L-TryptophanHCID 24386Thionyl Chloride

生成物 1

HCID 11666077Tryptophan butyl ester収率 181.9%

試薬・触媒・溶媒 1

HCID 2631-Butanol溶媒

反応条件

温度
100 °C

実験手順

L-Tryptophane (5 g; 24.5 mmol) and thionyl chloride (73.5 mmol; 5.3 ml) were dissolved in n-butanol (80 ml) and stirred at 100° C. over night. The product 5 precipitated after cooling to room temperature, was filtered off and washed with ice cold butanol and petrol ether. The product was dried at the oil pump, yielding 5.8 g of 5 (91%).

後処理

  1. customThe product 5 precipitated
  2. temperatureafter cooling to room temperature
  3. filtrationwas filtered off
  4. washwashed with ice cold butanol and petrol ether
  5. customThe product was dried at the oil pump

出典と根拠

ORDレコード
ord-4ed8fe63fe6941eca33ae882bbf034d6
出典データセット
uspto-grants-2014_09
特許番号
US08846682B2

関連ノート

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