L-Tryptophan → Tryptophan butyl ester
反応式
[NH2:1][C@H:2]([C:13]([OH:15])=[O:14])[CH2:3][C:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[NH:6][CH:5]=1.S(Cl)(Cl)=O>C(O)CCC>[CH2:13]([O:14][C:13](=[O:15])[C@H:2]([CH2:3][C:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[NH:6][CH:5]=1)[NH2:1])[CH2:2][CH2:3][CH3:4]参加物
4
反応条件
- 温度
- 100 °C
実験手順
L-Tryptophane (5 g; 24.5 mmol) and thionyl chloride (73.5 mmol; 5.3 ml) were dissolved in n-butanol (80 ml) and stirred at 100° C. over night. The product 5 precipitated after cooling to room temperature, was filtered off and washed with ice cold butanol and petrol ether. The product was dried at the oil pump, yielding 5.8 g of 5 (91%).
後処理
- customThe product 5 precipitated
- temperatureafter cooling to room temperature
- filtrationwas filtered off
- washwashed with ice cold butanol and petrol ether
- customThe product was dried at the oil pump
出典と根拠
- ORDレコード
- ord-4ed8fe63fe6941eca33ae882bbf034d6
- 出典データセット
- uspto-grants-2014_09
- 特許番号
- US08846682B2
反応ノート
読み込み中…