Sodium Hydroxide → HCID 20324959、化合物
反応式
[CH2:1]([C:5]1[N:10]2[N:11]=[CH:12][CH:13]=[C:9]2[N:8]=[C:7]([CH3:14])[CH:6]=1)[CH:2]([CH3:4])[CH3:3].[Br:15]N1C(=O)CCC1=O.[OH-].[Na+]>C(Cl)(Cl)Cl>[Br:15][C:13]1[CH:12]=[N:11][N:10]2[C:5]([CH2:1][CH:2]([CH3:4])[CH3:3])=[CH:6][C:7]([CH3:14])=[N:8][C:9]=12参加物
5
実験手順
A solution of 7.5 g (0.026 mol) of 7-isobutyl-5-methylpyrazolo-[1,5-a]pyrimidine in 60 ml chloroform was treated with 4.6 gm (0.026 mol) of N-bromosuccinimide. The mixture was stirred at ambient temperature and then allowed to cool overnight in the refrigerator. The mixture was then poured over ice (100 gm), rendered alkaline with 6N NaOH, and extracted with chloroform. The chloroform solution was separated, dried (Na2SO4), and distilled to yield 5.5 gm, (47%) of a light yellow, viscous oil, b.p. 127°-129° /1.5 mm.
後処理
- temperatureto cool overnight in the refrigerator
- extractionextracted with chloroform
- customThe chloroform solution was separated
- dry with materialdried (Na2SO4)
- distillationdistilled
- customto yield 5.5 gm, (47%) of a light yellow, viscous oil, b.p. 127°-129° /1.5 mm
出典と根拠
- ORDレコード
- ord-13be8c0a0b804772ab19f03deb2a628c
- 出典データセット
- uspto-grants-1978_06
- 特許番号
- US04093617
反応ノート
読み込み中…