4-Hydroxymethylpyridine → 4-(Chloromethyl)pyridinium chloride
反応式
O[CH2:2][C:3]1[CH:8]=[CH:7][N:6]=[CH:5][CH:4]=1.S(Cl)([Cl:11])=O>C(#N)C>[ClH:11].[Cl:11][CH2:2][C:3]1[CH:8]=[CH:7][N:6]=[CH:5][CH:4]=1参加物
4
実験手順
4-Hydroxymethylpyridine (20) (54.4 g, 0.50 mol) was dissolved in acetonitrile 202 ml. The solution was added dropwise to a mixture of thionyl chloride (65.3 g, 0.55 mol) and acetonitrile (109 ml) under 50° C. The mixture was stirred at the same temperature for 1 hour, then cooled to room temperature to yield a slurry (quantitative) of the objective (21).
出典と根拠
- ORDレコード
- ord-dee3bbe8fbf245858780f3dd89a7ddd2
- 出典データセット
- uspto-grants-2006_08
- 特許番号
- US07087764B2
反応ノート
読み込み中…