Sulfuric Acid → Dimedone

HRID 851802

反応式

HRID 851802 の反応式
[O:1]=[C:2]([CH3:11])[CH2:3][C:4]([CH3:10])([CH3:9])[CH2:5][C:6](O)=[O:7].S(=O)(=O)(O)O>C(Cl)(Cl)Cl>[CH3:9][C:4]1([CH3:10])[CH2:3][C:2](=[O:1])[CH2:11][C:6](=[O:7])[CH2:5]1

参加物

4

反応物 2

HCID 1118Sulfuric AcidHCID 113326103,3-Dimethyl-5-oxohexanoic acid

生成物 1

HCID 31358Dimedone収率 82.3%

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒

実験手順

A solution of 5 parts of 5-keto-3,3-dimethylhexanoic acid and about 15 parts of 73% sulfuric acid was heated for one hour in a 130°-135° oil bath. The cooled solution was then poured into a separatory funnel containing ice and chloroform. The aqueous phase was then washed three times with additional chloroform. The combined organic extractions were then dried and evaporated. There was obtained an 82.3% yield of dimedone. It was further recrystallized from toluene.

後処理

  1. additionThe cooled solution was then poured into a separatory funnel
  2. washThe aqueous phase was then washed three times with additional chloroform
  3. extractionThe combined organic extractions
  4. customwere then dried
  5. customevaporated

出典と根拠

ORDレコード
ord-d7eca5d1c32145dd995fe32b68df792d
出典データセット
uspto-grants-1983_05
特許番号
US04386222

関連ノート

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