Acetonitrile → HCID 58761682、化合物

HRID 857834ノート

反応式

HRID 857834 の反応式
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[CH:7]=[N:8][C@@H:9]1[CH2:14][CH2:13][CH2:12][CH2:11][C@H:10]1[N:15]=[CH:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][N:18]=1.[Pd:23]([Cl:25])[Cl:24].CC#N>C1COCC1>[Pd:23]([Cl:25])[Cl:24].[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[CH:7]=[N:8][C@@H:9]1[CH2:14][CH2:13][CH2:12][CH2:11][C@H:10]1[N:15]=[CH:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][N:18]=1

参加物

5

反応物 3

HCID 6342AcetonitrileHCID 24290Palladium ChlorideHCID 100629331-(pyridin-2-yl)-N-((1R,2R)-2-(((pyridin-2-yl)methylidene)amino)cyclohexyl)methanimine

生成物 1

HCID 58761682HCID 58761682、化合物

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

In a baked Schlenk tube, 1.0 g (3.4 mmol) of trans-N,N′-bispyridin-2-ylmethylenecyclohexane-1,2-diamine are dissolved in 40 ml of THF and admixed with 882 mg (3.4 mmol) of palladium(II) chloride*2 CH3CN. After 0.2 h, the solution becomes yellowish. After stirring at room temperature for another 2 hours, the solvent is removed under reduced pressure and the residue is stirred with 10 ml of heptane. Filtration through a G3 frit gives the product as a yellow solid in a yield of 1.45 g (2.92 mmol, 86%).

後処理

  1. customthe solvent is removed under reduced pressure
  2. stirringthe residue is stirred with 10 ml of heptane
  3. filtrationFiltration through a G3 frit

出典と根拠

ORDレコード
ord-af3080feb9cb4e44a94d87e18c41d0d3
出典データセット
uspto-grants-2006_12
特許番号
US07148174B2

反応ノート

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