Sodium Carbonate → 2-Amino-6-methyl-6-nitroheptanoic acid

HRID 858954ノート

反応式

HRID 858954 の反応式
[CH3:1][C:2]([N+:14]([O-:16])=[O:15])([CH3:13])[CH2:3][CH2:4][CH2:5][CH:6]1[NH:10]C(=O)N[C:7]1=[O:12].[OH-].[Na+].[OH-].[K+].C(=O)([O-])[O-:22].[Na+].[Na+].C(=O)([O-])[O-].[K+].[K+].[OH-].[Ca+2].[OH-].[OH-].[Ba+2].[OH-]>>[NH2:10][CH:6]([CH2:5][CH2:4][CH2:3][C:2]([CH3:1])([N+:14]([O-:16])=[O:15])[CH3:13])[C:7]([OH:12])=[O:22]

参加物

8

反応物 7

HCID 10340Sodium CarbonateHCID 11430Potassium CarbonateHCID 14797Potassium HydroxideHCID 14798Sodium HydroxideHCID 6093208Calcium HydroxideHCID 6093286Barium hydroxideHCID 99427025-(4-Methyl-4-nitropentyl)hydantoin2 回

生成物 1

HCID 219723372-Amino-6-methyl-6-nitroheptanoic acid

実験手順

5-(4-Methyl-4-nitropentyl)hydantoin is hydrolyzed with alkali to give 2-amino-6-methyl-6-nitroheptanoic acid (see JP-A-11-140076). For example, 5-(4-methyl-4-nitropentyl)hydantoin is hydrolyzed in an aqueous solution preferably in the presence of 1–3 equivalents of alkali, such as sodium hydroxide, potassium hydroxide, sodium carbonate, potassium carbonate, calcium hydroxide, barium hydroxide and the like, relative to 5-(4-methyl-4-nitropentyl)hydantoin generally at 20–200° C., preferably 100–150° C. The reaction mixture is concentrated to dryness to give 2-amino-6-methyl-6-nitroheptanoic acid. The obtained 2-amino-6-methyl-6-nitroheptanoic acid can be isolated and/or purified by a conventional method, such as crystallization, chromatography and the like, but generally, can be used in the next step without isolation and/or purification.

後処理

  1. customgenerally at 20–200° C.
  2. custompreferably 100–150° C
  3. concentrationThe reaction mixture is concentrated to dryness

出典と根拠

ORDレコード
ord-69e3344babe24f62aa870cd75b916878
出典データセット
uspto-grants-2006_12
特許番号
US07148371B2

反応ノート

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