Acetyl chloride → HCID 178418839、化合物

HRID 860123

反応式

HRID 860123 の反応式
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([CH3:8])[N:3]=1.[CH:9]1([N+:15]#[C-:16])[CH2:14][CH2:13][CH2:12][CH2:11][CH2:10]1.[N:17]1[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=1[CH:23]=O.[C:25]([Cl:28])(=[O:27])[CH3:26]>Cl(O)(=O)(=O)=O>[Cl-:28].[C:25]([N+:1]1[C:23]([C:18]2[CH:19]=[CH:20][CH:21]=[CH:22][N:17]=2)=[C:16]([NH:15][CH:9]2[CH2:14][CH2:13][CH2:12][CH2:11][CH2:10]2)[N:3]2[C:4]([CH3:8])=[CH:5][CH:6]=[CH:7][C:2]=12)(=[O:27])[CH3:26]

参加物

6

反応物 4

HCID 6367Acetyl chlorideHCID 142732-PyridinecarboxaldehydeHCID 157652-Amino-6-methylpyridineHCID 79129Cyclohexyl isocyanide

生成物 1

HCID 178418839HCID 178418839、化合物

試薬・触媒・溶媒 1

HCID 24247Perchloric Acid溶媒

実験手順

Example 17 was carried out in accordance with the general directions for synthesis in process step a) from 1.0 ml (0.1 mmol) 2-amino-6-methylpyridine (0.1 M, DCM), 0.575 ml (0.115 mmol) cyclohexylisonitrile solution (0.2 M, DCM), 0.500 ml (0.15 mmol) pyridine-2-carbaldehyde solution (0.3 M, DCM) and 10 μl perchloric acid (w=20%) and in process step c) and d) by reacting the resultant reaction product with 0.4 mmol acetylchloride.

出典と根拠

ORDレコード
ord-79c0b18a4d8e43db85b22433594b718b
出典データセット
uspto-grants-2006_12
特許番号
US07153873B2

関連ノート

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