Thionyl Chloride → 1-Benzyl-3-(chloromethyl)pyrrolidine

HRID 865

反応式

HRID 865 の反応式
[CH2:1]([N:8]1[CH2:12][CH2:11][CH:10]([CH2:13]O)[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.S(Cl)([Cl:17])=O>C(Cl)(Cl)Cl>[CH2:1]([N:8]1[CH2:12][CH2:11][CH:10]([CH2:13][Cl:17])[CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

4

反応物 2

HCID 24386Thionyl ChlorideHCID 5176654(1-Benzylpyrrolidin-3-yl)methanol

生成物 1

HCID 123645181-Benzyl-3-(chloromethyl)pyrrolidine

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒2 回

実験手順

To a refluxing solution of 15.3 g (0.08 mole) (3RS)-1-benzyl-3-hydroxymethyl pyrrolidine in 220 ml CHCl3 was slowly added a solution of 330 ml thionyl chloride in 60 ml CHCl3, and the reflux was continued for one hour. The mixture was evaporated and the residue was dissolved in water.

後処理

  1. customThe mixture was evaporated
  2. dissolutionthe residue was dissolved in water

出典と根拠

ORDレコード
ord-1537debbdfcd4c9fb2d97af472b6fc7c
出典データセット
uspto-grants-1998_03
特許番号
US05723444

関連ノート

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