Acetic Acid → 4-Bromo-2-chloro-6-(trifluoromethyl)aniline

HRID 880663

反応式

HRID 880663 の反応式
[Br:1]N1C(=O)CCC1=O.[Cl:9][C:10]1[CH:16]=[CH:15][CH:14]=[C:13]([C:17]([F:20])([F:19])[F:18])[C:11]=1[NH2:12].C(O)(=O)C>C(#N)C>[Br:1][C:15]1[CH:14]=[C:13]([C:17]([F:19])([F:18])[F:20])[C:11]([NH2:12])=[C:10]([Cl:9])[CH:16]=1

参加物

5

反応物 3

HCID 176Acetic AcidHCID 67184N-bromobutanimideHCID 27563842-Chloro-6-(trifluoromethyl)aniline

生成物 1

HCID 162179374-Bromo-2-chloro-6-(trifluoromethyl)aniline

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

N-bromosuccinimide (910 mg, 5.1 mmol) was added at room temperature to a solution of 2-chloro-6-(trifluoromethyl)aniline (1.0 g, 5.1 mmol) and acetic acid (3 mL) in acetonitrile (10 mL). The mixture was stirred at reflux to 18 h. The reaction mixture was then filtered through celite and concentrated to give the title compound, which was used in the next step without further purification.

後処理

  1. temperatureat reflux to 18 h
  2. filtrationThe reaction mixture was then filtered through celite and
  3. concentrationconcentrated

出典と根拠

ORDレコード
ord-e86951ee787845a19050816024630467
出典データセット
uspto-grants-2015_03
特許番号
US08993593B2

関連ノート

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