Diphenylsilane → 4-(4-Bromo-3-fluorobenzyl)morpholine

HRID 882966

反応式

HRID 882966 の反応式
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([N:10]2[CH2:15][CH2:14][O:13][CH2:12][CH2:11]2)=O)=[CH:4][C:3]=1[F:16].C1([SiH2]C2C=CC=CC=2)C=CC=CC=1>C1COCC1.C=O.C1C=CC(P(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1.C1C=CC(P(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1.C1C=CC(P(C2C=CC=CC=2)C2C=CC=CC=2)=CC=1.[Rh]>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][N:10]2[CH2:11][CH2:12][O:13][CH2:14][CH2:15]2)=[CH:4][C:3]=1[F:16]

参加物

5

反応物 2

HCID 69888DiphenylsilaneHCID 48474115(4-Bromo-3-fluorophenyl)(morpholin-4-yl)methanone

生成物 1

HCID 534178184-(4-Bromo-3-fluorobenzyl)morpholine

試薬・触媒・溶媒 2

HCID 53249357Carbonyltris(triphenylphosphine)rhodium(I)hydride触媒HCID 8028Tetrahydrofuran溶媒

実験手順

A 250 ml flask was charged with (4-bromo-3-fluorophenyl)(morpholino)methanone (4.569 g, 15.86 mmol) and dissolved in 16 mL of THF. Diphenylsilane (6.2 ml, 33.4 mmol) was added followed by carbonyltris(triphenylphosphine)rhodium(I)hydride (100 mg, 0.109 mmol) and the reaction stirred at room temperature for 20 hours.

出典と根拠

ORDレコード
ord-843b16ae77e44d478946b8a4599c9546
出典データセット
uspto-grants-2012_08
特許番号
US08236799B2

関連ノート

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