3-Hydroxypropionic acid → beta-Carboxyethyl 6,11-dihydro-11-oxodibenz[b,e]oxepin-2-carboxylate

HRID 894197ノート

反応式

HRID 894197 の反応式
Cl[C:2]([C:4]1[CH:19]=[CH:18][C:7]2[O:8][CH2:9][C:10]3[CH:17]=[CH:16][CH:15]=[CH:14][C:11]=3[C:12](=[O:13])[C:6]=2[CH:5]=1)=[O:3].[Na].[OH:21][CH2:22][CH2:23][C:24]([OH:26])=[O:25]>O1CCCC1>[O:13]=[C:12]1[C:11]2[CH:14]=[CH:15][CH:16]=[CH:17][C:10]=2[CH2:9][O:8][C:7]2[CH:18]=[CH:19][C:4]([C:2]([O:21][CH2:22][CH2:23][C:24]([OH:26])=[O:25])=[O:3])=[CH:5][C:6]1=2

参加物

5

反応物 3

HCID 681523-Hydroxypropionic acidHCID 5360545SodiumHCID 134560052-Chlorocarbonyl-6,11-dihydro-11-oxodibenz[b,e]oxepin

生成物 1

HCID 21162729beta-Carboxyethyl 6,11-dihydro-11-oxodibenz[b,e]oxepin-2-carboxylate

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

Dissolve 1.0 gm of 2-chlorocarbonyl-6,11-dihydro-11-oxodibenz[b,e]oxepin in 20 cc of tetrahydrofuran and add 1.0 gm of the sodium salt of β-hydroxypropionic acid. Stir the mixture at room temperature for 18 hours. Filter and evaporate the filtrate to dryness. Recrystallize the solid residue from ethanol to obtain the title product.

後処理

  1. filtrationFilter
  2. customevaporate the filtrate to dryness
  3. customRecrystallize the solid residue from ethanol

出典と根拠

ORDレコード
ord-1bf56c2a8e9b47169a1b159c92fee450
出典データセット
uspto-grants-1981_08
特許番号
US04282365

反応ノート

読み込み中…