1-Methylpiperazine → N-(6-Bromo-1,3-benzothiazol-2-yl)-N'-[4-(4-methylpiperazino)-4-oxobutyl]urea

HRID 9164

反応式

HRID 9164 の反応式
[Br:1][C:2]1[CH:22]=[CH:21][C:5]2[N:6]=[C:7]([NH:9][C:10]([NH:12][CH2:13][CH2:14][CH2:15][C:16]([O:18]CC)=O)=[O:11])[S:8][C:4]=2[CH:3]=1.[CH3:23][N:24]1[CH2:29][CH2:28][NH:27][CH2:26][CH2:25]1>C1COCC1>[Br:1][C:2]1[CH:22]=[CH:21][C:5]2[N:6]=[C:7]([NH:9][C:10]([NH:12][CH2:13][CH2:14][CH2:15][C:16]([N:27]3[CH2:28][CH2:29][N:24]([CH3:23])[CH2:25][CH2:26]3)=[O:18])=[O:11])[S:8][C:4]=2[CH:3]=1

参加物

4

反応物 2

HCID 531671-MethylpiperazineHCID 21985597Ethyl 4-([(6-bromo-1,3-benzothiazol-2-yl)amino]carbonylamino)butanoate

生成物 1

HCID 21985590N-(6-Bromo-1,3-benzothiazol-2-yl)-N'-[4-(4-methylpiperazino)-4-oxobutyl]urea収率 58.7%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

Ethyl 4-([(6-bromo-1,3-benzothiazol-2-yl)amino]carbonylamino)butanoate (100 mg, 0.259 mmol) was heated neat at about 80° C. in N-methyl-piperazine (259 mg, 2.59 mmol) for about 8 hrs. To the crude reaction mixture was added THF (2 mL), the ppt was filtered off and washed with THF (1 mL). The product was dried in vacuo and gave 67 mg (53%) pure product.

後処理

  1. customTo the crude reaction mixture
  2. filtrationthe ppt was filtered off
  3. washwashed with THF (1 mL)
  4. customThe product was dried in vacuo

出典と根拠

ORDレコード
ord-a7c760657744469984c092df1b5dee3f
出典データセット
uspto-grants-2006_08
特許番号
US07091227B2

関連ノート

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